Harshabad Singh, MBBS
Dana-Farber Cancer Institute
2019 William Raveis Charitable Fund Fellowship
Cancers involving the lower esophagus have dramatically increased in number over the last several decades. The reason for rise in this cancer is not completely understood; it may be related to smoking, alcohol, or even acid reflux. However, long before these esophageal cancers develop, the normal lining of the esophagus changes, possibly as a result of stomach cells migrating upward. This new tissue is called “Barrett’s esophagus” and is more likely to progress to cancer.. Dr. Singh proposes to investigate the origins of Barrett’s esophagus and understand its specific vulnerability to progress to cancer. This work may lead to new preventive strategies for esophageal cancers.